In order to fully understand CBD (Cannabidiol), we must understand all the relationships between the human body and Cannabis.

So let's start by getting more familiar with CBD

What is CBD?

That is an abbreviation of Cannabidiol. This is a naturally occurring cannabinoid component of Cannabis. This ingredient is most known for its healing properties without the patient feeling impaired. This is only 1 of 120 known cannabinoids and some experts believe there are many more to be discovered.

Why are Cannabinoids Special?

The Human body has a neurotransmitter network known as the Endogenous Cannabinoid System (ECS). The body naturally produces endocannabinoids (endo meaning internal; within) to achieve homeostasis (meaning tendency toward a relatively stable equilibrium despite external or internal changes to the environment).

To simplify, the ECS is designed to keep the body in balance. The cannabinoids (CB's) found in the plant are known as phytocannabinoids. The ECS is able to use the communication coming from the phytocannabinoids and produce endocannabinoids which help the body to produce the desired healing effects.


What ways can CBD be taken?

  • Sublingual (Under the Tongue) Hemp Oil Drops
  • Topically like Cream, Lotion, and Salve
  • Edibles like Gummies
  • Digestible like Softgels
  • Trans-dermal Applications like Pain Patches


What's Right for Me?

That depends on your preference and/or goals.

Sublingual Hemp Oil Drops:

  • Absorbed quickest by the body
  • Can treat most common issues
  • Spreads vast throughout the body providing complete body support
  • Builds up in the body to provide long-term benefits


  • Targeted delivery to affected areas for pain, inflammation, and discomfort
  • Rejuvenation of the skin
  • Protection or removal of harmful bacteria


  • Absorbed slower than Sublingual but lasts longer
  • Absorbed with other assisting nutrients in their delivery and efficacy
  • Can be quite yummy
  • Watch for sugars and / or artificial flavors


  • Similar to Edibles being absorbed slower but lasts longer
  • Pharmaceutical Grade Softgels are scientifically designed to absorb better than an Edible
  • Accurate dosing
  • Stable structure of CBs which keeps the product effective over time and movement

Trans-dermal Application:

  • Targeted delivery and releases over an extended period of time
  • Best for chronic pain in a specific flat surfaced area like the back
  • You will wearing a sticker so may not be the most comfortable option


Now let's explore how CBD is made

Phytocannabinoids are the key components of Hemp or Cannabis. The highest concentration of phytocannabinoids come from Cannabis Sativa. The two are still in the same class. Hemp is better for industrial purposes and Cannabis Sativa is better for Medical Applications.

How is Phytocannabinoid-Rich Hemp Oil Made?

There are a various type of extraction methods with both having pros and cons. The best way in our opinion, is to use an Ethanol (alcohol) extraction. This process preserves the essential oils and naturally ocurring terpenes (flavor and vitamins). This method provides a Full Spectrum Distillate rich of all the healing properties of the plant in the most organic fashion.

The other most popular method is CO2 Supercritical Extraction. This at one time was thought to be better than Ethanol because it minimizes product waste and potential risk of toxins. However, after deeper exploration, the quality was not as good due to the increased temperature and disturbance to the cannabinoids therefore reducing overall efficacy.

What is Full Spectrum?

This is the type of extract that is rich of phytocannabinoids and synergistic compounds such as CBD, CBG, CBN, CBC, and over 40 naturally preserved terpenes. This is known as The Entourage Effect.  

The principle is based on the observation that the cannabinoids work very well together. Most Physicians would agree that Full Spectrum is significantly better than Isolated CBD.

Full Spectrum hemp oil prevents enzyme FAAH (Fatty Acid Amid Hydrolase) from breaking down all of the Anandamide (N-arachidonoylethanolamine or AEA), and therefore makes more of it available for use by your cells. That is why Full Spectrum works better and provides longer lasting benefits.

Each cannabinoid can assist with treatment for a variety of conditions:


Let's Have a Deeper Look!

In order to fully understand the potential of these CB's, we must be clear on what these CB's are actually doing in the body.

What is Anandamide?

This is neurotransmitter and an endocannabinoid produced by the human body. The name is taken from Sanskrit word "ananda," which mean joy, bliss, or delight. This "bliss" molecule is very similar to the phytocannabinoid molecules.



Anandamide interacts with both CB1 and CB2 receptors. The molecule is considered fragile since it breaks down very quickly. This also plays an important role in many physiological processes like pain, appetite, and fertility. In 1998, a group of Italian scientists found that anandamide effectively slowed the formation of unwanted breast tissue. In 2005, an article in the Journal of Clinical Investigation, it stated that anandamide and other cannabinoids promoted neurogenesis (growth and development of nervous tissue) in the hippocampus (the part of the brain responsible for managing memory, learning, and emotion) and have an antidepressant-like effect.

We produce anandamide when we exercise, hence the term "runner's high." Until recently, scientist believed that was caused by endorphins. However, new research suggests otherwise. We also get increased anandamide from eating chocolate and truffles.

Now that we know how endocannabinoids are produced, let's see exactly how they help.

















How do Endocannabinoids Help?

The endocannabinoid system is like a security guard that is always watching over your body and ready to take action anytime there is a disturbance. Our neuron's transmit signal in response to stimulus. The endocannabinoids attach to their receptors and calm down the neurons to achieve homeostasis and balance in the body. This is why cannabinoids are so great for pain and other conditions.

The CB's have the ability to inhibit inflammation by binding to the CB2 receptors of the cytokine-producing immune cells (white blood cells). This is known as apoptosis (cell death) of the immune cells.

Research studies have already proven that low levels of endocannabinoids are present in many diseases and disorders. The goal is to maintain a healthy level of CB's in the body.

Ways to correct endocannabinoid system deficiency:

  • Consume foods that are rich in omega-3 fatty acids like seafood, walnuts, and spinach
  • Eat foods that are rich in polyphenols like nutmeg and tumeric
  • Exercise
  • Finally, a supplement of exogenous phytocannabinoids like CANNERA Full Spectrum CBD

Deficiencies of endocannabinoids can be due to genetics, poor nutrition, or the environment. Some problematic conditions that can arise are migraines, fibromyalgia, and IBS (irritable bowel syndrome).

Now let's go even deeper... or should we say smaller?

Now that we understand how cannabinoids work and the benefits they provide, where do we go from here?

What is Advanced Micro & Nano CBD?

Evolution is the next step. In order to provide even more benefits without the need of synthetic drugs, the answer is the micronization (reduction of the average diameter of a solid materials particles) of the phytocannabinoid molecules.

Smaller particles lead to better absorption. CANNERA has partnered with a lab that has a patent-pending technology that transforms active compounds into nano-sized emulsions, making them highly bio-available and more permeable when applied to the skin.

CANNERA created a 3-Step Phytocannabinoid Wellness System designed to provide optimal endocannabinoid levels for 24 hours. This will provide even more balance (homeostasis) than regular CBD. Long-term effects will be noticed after 14 days of suggested use.

Particles sizes are measured in nanometers. The average particle of a phytocannabinoid is apx. 1,000 nanometers. The average droplet size for our Nano CBD products are 25 nanometers and the average for our Micro CBD products are 100 nanometers. Technically they are both nano-emulsions. We classified the 2 differently to make aware of the difference in size.

A softgel provides support to the stability of the phytocannabinoid particles. Loose particles in sublingual CBD drops will move freely and therefore cannot constrain the particles to 25 nanometers without damaging them. However, the sublingual CBD acts quickly and permeates through the skin's cell membrane known as in-vivo absorption.


Are Nanoemulsified Cannabinoids better than Natural CBD Hemp Oil?

The short answer, it depends.

For most common conditions one would turn to for over the counter medication, Full Spectrum Organic CBD is more than sufficient. The average adult's ECS (Endocannabinoid System) should maintain proper levels by taking 2-3 doses per day.

You should always seek the advice of a licensed Physician prior to making any dramatic changes to your medication or if you have questions pertaining to our products. There is so much information available regarding the impact of cannabinoids in the human body. We hope you continue to research cannabinoids and anything that can be of service to you.  


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